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Muromonab-CD3

Generic name: muromonab-cd3 [ MUE-roe-MOE-nab-CD-3 ]
Brand name: Orthoclone OKT 3

Muromonab-CD3 may cause serious allergic reactions. These may occur at any time while you use muromonab-CD3. It may also cause other serious and sometimes fatal effects, including heart and nervous system problems. Tell your doctor right away if you experience shortness of breath; chest pain; numbness of an arm or leg; sudden severe dizziness, headache, nausea, or vomiting; fainting; severe stomach pain; trouble speaking; vision changes (eg, light sensitivity or blindness); one-sided weakness; seizures; or paralysis after you receive muromonab-CD3.

You should only receive muromonab-CD3 in a health care facility where you can receive proper treatment in case you have a severe allergic reaction or other severe side effects.

Your doctor may give you another medicine (methylprednisolone) to help lower the risk of certain severe side effects from muromonab-CD3.


Muromonab-CD3 is used for:

Treating organ rejection after a kidney transplant. It is also used to treat organ rejection in patients with a heart or liver transplant if corticosteroids do not work well. It may also be used for other conditions as determined by your doctor.

Muromonab-CD3 is an immunosuppressant. It blocks the action of certain blood cells (eg, T lymphocytes) that can cause the body to reject the transplanted organ.

Do NOT use muromonab-CD3 if:

Contact your doctor or health care provider immediately if any of these apply to you.

Before using muromonab-CD3:

Some medical conditions may interact with muromonab-CD3. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with muromonab-CD3. Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if muromonab-CD3 may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use muromonab-CD3:

Use muromonab-CD3 as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about the proper use of muromonab-CD3.

Important safety information:

Possible side effects of muromonab-CD3:

Every medicine can cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Decreased appetite; diarrhea; dizziness; fatigue; flushing; headache; increased sweating; nausea; nervousness; tiredness or weakness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or tarry stools; calf pain/tenderness; chest pain; confusion; decreased hearing/deafness; decreased urination; fainting; fast, slow, or irregular heartbeat; fever; hallucinations; hoarseness; mental or mood changes; muscle or joint aches or pain; neck soreness or stiffness; numbness of an arm or leg; one-sided weakness; paralysis; seizures; severe or persistent tiredness, weakness, nausea, vomiting, or diarrhea; shortness of breath; signs of infection (eg, chills, fever, sore throat); skin thickening, growths, or color change; speech changes; stomach pain; sudden severe dizziness or headache; swelling of the arms, legs, hands, or feet; tremor; trouble swallowing; uncontrolled muscle movements; unusual bruising or bleeding; unusual lumps; vision changes (eg, blindness, sensitivity to light); wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include decreased urination; diarrhea; fever; muscle pain; severe chills; shortness of breath; swelling; or vomiting.

Proper storage of muromonab-CD3:

Muromonab-CD3 is usually handled and stored by a health care provider. If you are using muromonab-CD3 at home, store muromonab-CD3 as directed by your pharmacist or health care provider. Keep muromonab-CD3 out of the reach of children and away from pets

General information:

This information should not be used to decide whether or not to take muromonab-CD3 or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about muromonab-CD3. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to muromonab-CD3. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using muromonab-CD3.

Issue Date: June 3, 2015

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.